• Bioinformatics Scientist with proven track record in protein structure/sequence and DNA analysis
• Software Engineer with 40+ years experience in commercial and academic settings
• Proven ability to enter a new environment, identify opportunities and then design and deliver solutions
• Self-starting fast learner enjoying new challenges and application areas
• Creative problem solver with strong communication skills and supportive attitude to bring out a group's very best
• Expertise across scientific, technical and people domains

• Independent Developer, 2016-present:
  • Internal coordinates infrastructure for Biopython; [2021 Update]
  • Movable, H-bonded polypeptide model
  • Lua classes and modules to build, manipulate and analyse protein structures
  
  
• Realidata, Ltd.: iOS Software and Bioinformatics Consulting
  • 2011-2017 CEO
  • rTracker iOS app (source code)
  • abYsis support work.
  
  
• Heptares Therapeutics: GPCR stabilisation and drug discovery
• 2011-2015 Principal Scientist:
• Created software to predict GPCR stabilising mutations from sequence and 3D structure data, achieved ca. 80% accuracy
• Created compound management system for inventory and location tracking of in house samples
• Created docking server for chemists to run docking protocols developed by chemoinformaticians
• Created text analysis sysem to crawl PubMed/MeSH data for orphan diseases with GPCR link indications
• Developed and maintained Dotmatics chemoinformatics management system (JavaScript on Oracle backend)


• Molecular Biotechnology Group, National Biotechnology Development Agency (NABDA/FMST), Abuja, Nigeria
  • 2008-10 Consultant for creation of national bioinformatics center
  
  
• AfriConnect Zambia: Internet Service Provider
  • 2006-10 Senior Technical Consultant
    • Software development: create and maintain web interfaces for system monitoring and manipulation by support staff; automate system/client management
    • Staff training: design and implementation of existing network; Linux
    • Network administration for 1,000 client satellite/wireless broadband ISP in Lusaka
    • Manage local VSAT connection for remote work


• West African Biotechnology Workshops (WABWS)
  • 2003,05 Lecturer for workshops at University of Ibadan, Nigeria
    • Perl Programming
    • Protein Structure and HIV
  
  
• Inpharmatica, Ltd., 60 Charlotte St., London W1P 2AX.
  • 1999-03 Associate Director, Research Informatics
  • Programmer/Analyst
  • Line-manager for 9-15 Bioinformaticians.
  • Major projects covering genome annotation, gene finding, protein annotation.
  • Extensive role as interface between scientists and IT specialists.
  
  
• South African National Bioinformatics Institute (SANBI) (laboratory of Dr. Winston Hide), University of the Western Cape, Bellville, South Africa
  • 1996-99 Postdoctoral Research Fellow & Manager, Durban Satellite
    • Created and managed bioinformatics lab to support Virology Department, Nelson Mandela School of Medicine, Durban, South Africa
    • Developed STACK clustered EST database and STACK-PACK, the toolset to create it.
    • Licensed by over 100 sites (commercial and academic) worldwide.
  
  
• University College London (laboratory of Prof. Janet Thornton, FRS, DBE)
  • 1994-96 Postdoctoral Research Fellow
    • THREADER testing and GUI development.


• Pacific Northwest National Laboratory
  • 1992-93 NORCUS Appointee: Developed protein structure analysis tools in C and Lisp


• Washington State University
  • 1989-92 Research Assistant: Developed inter-processor communication protocol for atmospheric hydroxyl radical monitor.


• Molecular Kinetics/BioLogic
• 1987-90 Technical Consultant Sole technical support on North American continent for BioLogic rapid kinetics equipment.


• Maverick International
• 1985-87 Embedded Systems Software Engineer: Assembly language firmware development

• Dar es Salaam Yacht Club, Dar es Salaam, Tanzania
• 2017-21 Club Secretary, Dive Section
• 2017-21 Dive Leader, Dive Section
• American International School of Abuja (AISA), Abuja, Nigeria
  • 2004-05 Board President and Chair of Strategic Policy and Planning Committee
  • Team leader: initiated development of first expatriate secondary school in Abuja (3rd graduating class in 2011)
  • Team member: initiated creation of multi-million dollar new school for capital of largest country in Africa
  • 2003-04 Board Secretary

• Current: Actively working with OpenSCAD, Python, Objective-C, SQL (PostgreSQL, SQLite, Oracle, MySQL), HTML, iOS, Mac OS X, Linux, 3D printing

• Previous: Extensive experience with Lua, Perl, C, C++, Tcl, Lisp, assembly code, Fortran; Unix, Gnome, Qt, X11, MS-Windows/DOS, AmigaDOS, VAX/VMS; PC Hardware, Intel Touchstone Delta, Maspars; 2-D PAGE; CD, UV-Vis and NMR spectroscopy; logic analyzers, oscilloscopes, solder; auto mechanics.

• New: Easily acquire new skills on a project basis, particularly as regards computer technologies and languages

• Interdisciplinary Ph.D., Biochemistry, Computer Science, and Chemistry; Washington State University, Spring 1994.
  • dissertation: Bioinformatic Approaches to Protein Structural Analysis
  • Tektronix Fellow, NORCUS Appointee.
  • Keith Dunker lab
• M.S., Biochemistry, Washington State University, Autumn, 1991.
  • emphases: protein structure, computational and instrumental approaches.
• M.S., Computer Science, Washington State University, Summer, 1991.
  • emphases: artificial intelligence, graphics, theory of computation.
• B.A, B.S., Liberal Arts, The Evergreen State College, 1985.
  • US history, political economics, biological sciences, electronics.
  • terms of study in: D.J. Evans U.S. Senate office; E. Kutter T4 phage lab; Buenos Aires, Argentina.

First Author

• ''A comprehensive approach to clustering of expressed human gene sequence: the Sequence Tag Alignment and Consensus Knowledgebase,'' Miller, Christoffels, Burke, Ptitsyn, Broveak, and Hide, Genome Research 1999 9(11);1143-55.
• ''Protein Fold Recognition by Sequence Threading: Tools and Assessment Techniques,'' Miller, Jones, and Thornton, FASEB Journal 1996 10(1);171-8.
• ''Development and Application of a Three-dimensional Description of Amino Acid Environments in Protein,'' Miller, Douthart, and Dunker, Advances in Molecular Bioinformatics, IOS Press, 1994, ISBN 90 5199 172 x, pp. 9-30.
• ''An alphabet of Amino Acid Conformations in Protein,'' Miller, Douthart, and Dunker, Proceedings of the 26th Hawaii International Conference on System Sciences, IEEE Computer Society Press, 1993. ISBN: 0-8186-3230-5.
• ''Learning an Objective Alphabet of Amino Acid Conformations in Protein,'' Miller, Douthart, and Dunker, Techniques in Protein Chemistry IV, Academic Press, 1993, pp. 541-548.
• ''Identifying Repeated Structural Elements in Folded Proteins,'' Miller, Douthart, and Dunker, Proceedings of the 27th Hawaii International Conference on System Sciences, IEEE Computer Society Press, 1994.

Other

• ''An integrated genetic data environment (GDE)-based LINUX interface for analysis of HIV-1 and other microbial sequences,'' De Oliveira, Miller, Tarin and Cassol, Bioinformatics 2003.
• ''Application of high-throughput computing in bioinformatics,'' Swindells, Rae, Pearce, Moodie, Miller and Leach, Philosophical Transactions of the Royal Society A.
• ''STACK: Sequence Tag Alignment and Consensus Knowledgebase,'' Christoffels, van Gelder, Greyling, Miller, Hide, and Hide, Nucleic Acids Research 2001.
• ''A novel approach towards a comprehensive consensus representation of the expressed human genome,'' Hide, Burke, Christoffels and Miller, Genome Informatics 1997.
• ''Conformational changes in a mammalian voltage-dependent potassium channel inactivation peptide,'' Abbott, Mercer, Miller, Ramesh and Srai, Biochemistry 1998.
• ''Secondary structure, stability and tetramerisation of recombinant K(V)1.1 potassium channel cytoplasmic N-terminal fragment,'' Abbott, Bloemendal, Van Stokkum, Mercer, Miller, Sewing, Wolters, Pongs and Srai, Biochim Biophys Acta 1997.
• ''Successful Protein Fold Recognition by Optimal Sequence Threading Validated by Rigorous Blind Testing,'' Jones, Miller and Thornton, Proteins 1995.

Older Open Source Contributions

• fixes to 386BSD iso9660 filesystem to support Brookhaven PDB cdroms
• minor pilot-link work
• smcinit, initialiser for IrDA subsystem on some Toshiba laptops.
• Linux driver for Synaptics cPad mousepad
• Prozect, a hierarchical outliner and to-do list for the Sharp Zaurus PDA
• Linux driver for Kensington Expert Mouse Pro trackball
• Piccel, an editor for ICC Color Profiles under Linux